diff --git a/synapse/handlers/profile.py b/synapse/handlers/profile.py
index bf91eedb7f..a06f596248 100644
--- a/synapse/handlers/profile.py
+++ b/synapse/handlers/profile.py
@@ -45,16 +45,14 @@ class ProfileHandler(BaseHandler):
 
         self.http_client = hs.get_simple_http_client()
 
-        self.clock.looping_call(self._update_remote_profile_cache, self.PROFILE_UPDATE_MS)
-
         if hs.config.worker_app is None:
             self.clock.looping_call(
                 self._update_remote_profile_cache, self.PROFILE_UPDATE_MS,
             )
 
-        reactor.callWhenRunning(self._assign_profile_replication_batches)
-        reactor.callWhenRunning(self._replicate_profiles)
-        self.clock.looping_call(self._replicate_profiles, self.PROFILE_REPLICATE_INTERVAL)
+            reactor.callWhenRunning(self._assign_profile_replication_batches)
+            reactor.callWhenRunning(self._replicate_profiles)
+            self.clock.looping_call(self._replicate_profiles, self.PROFILE_REPLICATE_INTERVAL)
 
     @defer.inlineCallbacks
     def _assign_profile_replication_batches(self):