diff --git a/vector/src/main/java/im/vector/app/features/home/room/detail/timeline/item/MessageAudioItem.kt b/vector/src/main/java/im/vector/app/features/home/room/detail/timeline/item/MessageAudioItem.kt
index 8d5810a60a..397f43546e 100644
--- a/vector/src/main/java/im/vector/app/features/home/room/detail/timeline/item/MessageAudioItem.kt
+++ b/vector/src/main/java/im/vector/app/features/home/room/detail/timeline/item/MessageAudioItem.kt
@@ -16,6 +16,7 @@
 
 package im.vector.app.features.home.room.detail.timeline.item
 
+import android.content.Context
 import android.content.res.ColorStateList
 import android.graphics.Color
 import android.graphics.Paint
@@ -105,11 +106,20 @@ abstract class MessageAudioItem : AbsMessageItem<MessageAudioItem.Holder>() {
     }
 
     private fun bindViewAttributes(holder: Holder) {
+        val formattedDuration = formatPlaybackTime(duration)
+        val formattedFileSize = TextUtils.formatFileSize(holder.rootLayout.context, fileSize, true)
+        val durationContentDescription = getPlaybackTimeContentDescription(holder.rootLayout.context, duration)
+
         holder.filenameView.text = filename
         holder.filenameView.onClick(attributes.itemClickListener)
         holder.filenameView.paintFlags = (holder.filenameView.paintFlags or Paint.UNDERLINE_TEXT_FLAG)
-        holder.audioPlaybackDuration.text = formatPlaybackTime(duration)
-        holder.fileSize.text = TextUtils.formatFileSize(holder.rootLayout.context, fileSize, true)
+        holder.audioPlaybackDuration.text = formattedDuration
+        holder.fileSize.text = holder.rootLayout.context.getString(
+                R.string.audio_message_file_size, formattedFileSize
+        )
+        holder.mainLayout.contentDescription = holder.rootLayout.context.getString(
+                R.string.a11y_audio_message_item, filename, durationContentDescription, formattedFileSize
+        )
     }
 
     private fun bindSeekBar(holder: Holder) {
@@ -172,6 +182,12 @@ abstract class MessageAudioItem : AbsMessageItem<MessageAudioItem.Holder>() {
 
     private fun formatPlaybackTime(time: Int) = DateUtils.formatElapsedTime((time / 1000).toLong())
 
+    private fun getPlaybackTimeContentDescription(context: Context, time: Int): String {
+        val formattedPlaybackTime = formatPlaybackTime(time)
+        val (minutes, seconds) = formattedPlaybackTime.split(":").map { it.toIntOrNull() ?: 0 }
+        return context.getString(R.string.a11y_audio_playback_duration, minutes, seconds)
+    }
+
     override fun unbind(holder: Holder) {
         super.unbind(holder)
         contentUploadStateTrackerBinder.unbind(attributes.informationData.eventId)
diff --git a/vector/src/main/res/values/strings.xml b/vector/src/main/res/values/strings.xml
index 90f6c5f7b1..1e50b32c6b 100644
--- a/vector/src/main/res/values/strings.xml
+++ b/vector/src/main/res/values/strings.xml
@@ -2860,10 +2860,13 @@
     <string name="error_voice_message_cannot_reply_or_edit">Cannot reply or edit while voice message is active</string>
     <string name="voice_message_reply_content">Voice Message (%1$s)</string>
 
+    <string name="a11y_audio_message_item">%1$s, %2$s, %3$s</string> <!-- filename, duration, file size -->
+    <string name="a11y_audio_playback_duration">%1$d minutes %2$d seconds</string>
     <string name="a11y_play_audio_message">Play %1$s</string>
     <string name="a11y_pause_audio_message">Pause %1$s</string>
     <string name="error_audio_message_unable_to_play">Unable to play %1$s</string>
     <string name="audio_message_reply_content">%1$s (%2$s)</string>
+    <string name="audio_message_file_size">(%1$s)</string>
 
     <string name="upgrade_room_for_restricted">Anyone in %s will be able to find and join this room - no need to manually invite everyone. You’ll be able to change this in room settings anytime.</string>
     <string name="upgrade_room_for_restricted_no_param">Anyone in a parent space will be able to find and join this room - no need to manually invite everyone. You’ll be able to change this in room settings anytime.</string>